【药物名称】
化学结构式(Chemical Structure):
参考文献No.471976
标题:Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors. Use of L-mannaric acid as a peptidomimetic scaffold
作者:Alterman, M.; Bj鰎sne, M.; M黨lman, A.; Classon, B.; Kvarnstrom, I.; Danielson, H.U.; Markgren, P.O.; Nillroth, U.; Unge, T.; Hallberg, A.; Samuelsson, B.
来源:J Med Chem 1998,41(20),3782
合成路线图解说明:

Oxidation of L-mannonic gamma-lactone (I) with aqueous nitric acid provided bislactone (II). Subsequent treatment of bislactone (II) with benzyl trichloroacetimidate (III) and trifluoromethanesulfonic acid furnished dibenzyl ether (IV). Then, nucleophilic opening of both lactone groups of (IV) with (1S,2R)-1-amino-2-indanol (V) in refluxing dichloromethane yielded the title bisamide.

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