【药物名称】
化学结构式(Chemical Structure):
参考文献No.469557
标题:Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors
作者:Wagner, J.; Kallen, J.; Ehrhardt, C.; Evenou, J.-P.; Wagner, D.
来源:J Med Chem 1998,41(19),3664
合成路线图解说明:

Coupling of thiazolopyridine (I) with amine (II) in the presence of EDC and HOBt provided amide (III). Deprotection of the Fmoc group of (III) was effected with piperidine in CH2Cl2 and the resulting amine (IV) was condensed with benzylsulfonyl chloride (V) to afford sulfonamide (VI). Finally, both Boc protecting groups of (VI) were removed with TFA to yield the title guanidine as the bis(trifluoroacetate) salt.

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