F-12985-药物合成数据库

【药物名称】F-12985

化学结构式(Chemical Structure):

参考文献No.	480709
标题:	Novel phthalazine derivatives with high dopamine D
作者:	Prinssen, E.P.M.; Schambel, P.; Monse, B.M.; Koek, W.; Kleven, M.S.; Assi? M.-B.; Diard, C.; Imbert, T.
来源:	15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998,Abst P.167

合成路线图解说明: Benzoic acid (I) was condensed with hydrazine sulfate in the presence of NaOAc to afford phthalazinone (II). Further treatment of (II) with phosphoryl chloride at 80 C gave the 1-chlorophthalazine (III). Then, substitution of the halogen atom for N-benzyl-3-(exo)-aminotropane (IV) at 100 C provided the title compound.

合成路线图解说明: Benzoic acid (I) was condensed with hydrazine sulfate in the presence of NaOAc to afford phthalazinone (II). Further treatment of (II) with phosphoryl chloride at 80 C gave the 1-chlorophthalazine (III). Then, substitution of the halogen atom for N-benzyltropan-3-(exo)-ol (IV) in refluxing THF provided the title compound.