【药物名称】L-818571
化学结构式(Chemical Structure):
参考文献No.37367
标题:Pyridazinones as inhibitors of cyclooxygenase-2
作者:Therien, M.; Li, C.S.; Lau, C.K.; Prasit, P.; Gauthier, J.Y. (Merck Frosst Canada Inc.)
来源:EP 0975604; US 6004960; WO 9841511
合成路线图解说明:

Cyclization of hydroxyfuranone (I) with hydrazine in refluxing EtOH produced the pyridazinone (II), which was subsequently alkylated with cyclopropylmethyl bromide (III) in the presence of NaOH to afford the title compound.

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