【药物名称】SB-237596
化学结构式(Chemical Structure):
参考文献No.33848
标题:Heterocycle-condensed morphinoid derivs. (II)
作者:Dondio, G.; Ronzoni, S.; Gatti, P.A.; Graziani, D. (SmithKline Beecham SpA)
来源:EP 0880526; JP 2000503019; WO 9725331
合成路线图解说明:

The compound was prepared by condensation of dihydrocodeinone hydrochloride (I) with N-Benzyl-N-isopropyl-2-(phenylhydrazono)-3-oxobutyramide (II) in the presence of zinc dust and NaOAc in refluxing AcOH.

合成路线图解说明:

The compound was prepared by condensation of dihydrocodeinone hydrochloride (I) with N-Benzyl-N-isopropyl-2-(phenylhydrazono)-3-oxobutyric acid isobutyl ester (II) (II) in the presence of zinc dust and NaOAc in refluxing AcOH.

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