Artemisinin (I) was reduced to the dihydro analogue (II), and subsequently the 10-hydroxyl group was substituted for a fluorine atom using diethylaminosulfur trifluoride. The desired 10-beta-isomer (III) was then separated by column chromatography. Finally, boron trifluoride-promoted Friedel Crafts condensation with furan (IV) at low temperature provided the target furyl compound, the major 10-beta isomer being isolated by chromatography on Florisil.