【药物名称】
化学结构式(Chemical Structure):
参考文献No.469883
标题:Condensed heterocyclic compounds: Synthesis and antiinflammatory activity of novel thiazolo[3,2-a]pyrimidines
作者:Kelicen, P.; Ertan, M.; Demirdamar, R.; Krebs, B.; Tozkoparan, B.; L鋑e, M.
来源:Arch Pharm 1998,331(6),201
合成路线图解说明:

The cyclization of methyl acetoacetate (I), 2-methoxybenzaldehyde (II) and thiourea (III) by means of HCl in refluxing ethanol gives the tetrahydropyrimidine (IV), which is finally cyclized with chloroacetic acid (V) and benzaldehyde (VI) by means of sodium acetate in a refluxing mixture of acetic acid and acetic anhydride.

参考文献No.556259
标题:Pharmacokinetics of a new antihypertensive pyrrolyl pyridazinamine (MDL-899) in the rat and the dog
作者:Assandri, A.; et al.
来源:Arzneim-Forsch Drug Res 1985,35(2),508
合成路线图解说明:

The starting compound is 3,6-dichloropyridazine (I), which is reacted with morpholine (II) in a suitable solvent to give 3-morpholino-6-chloropyridazine (III). This, upon reaction with hydrazine hydrate as solvent, gives the hydrazine derivative (IV), which by reaction with acetonylacetone (V) in acetic acid yields directly the title compound. [14C]-Labeled compound is synthesized by a microscale procedure with 45% chemical yield and 98% radiochemical purity.

合成路线图解说明:

The cyclization of methyl acetoacetate (I), 2-methoxybenzaldehyde (II) and thiourea (III) by means of HCl in refluxing ethanol gives the tetrahydropyrimidine (IV), which is finally cyclized with chloroacetic acid (V) and benzaldehyde (VI) by means of sodium acetate in a refluxing mixture of acetic acid and acetic anhydride.

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