RGH-1756-药物合成数据库

【药物名称】RGH-1756

化学结构式(Chemical Structure):

参考文献No.	36503
标题:	2-Methoxyphenylpiperazine derivs.
作者:	Laszlovszky, I.; Dom醤y, G.; Ferenczy, G.; Sz醤tay, C. Jr.; Thuroczyn?K醠m醤, E.; Lapis, E.; Trischler, F.; Heged鷖, B.; Auth, F.; Csejtei, M.; K醨p醫i, E.; Kiss, B.; Laszy, J.; Pellioniszn?Par骳zai, M.; Sarkadi, A.; Szab? S. (Gedeon Richter Ltd.)
来源:	EP 0935599; US 6103724; WO 9818797

合成路线图解说明: By condensation of 1-(2-methoxyphenyl)piperazine (I) with 6-[4-(4-chlorobutoxy)phenyl]imidazo[1,2-b]thiazole (II) by means of Na2CO3/NaI in refluxing methyl isobutyl ketone.

合成路线图解说明: Coupling between phenol derivative (I) and 1-bromo-4-chlorobutane (II) by means of either Na2CO3/NaI or K2CO3 in refluxing 5-methyl-2-hexanone affords 4-chlorobutoxy derivative (III), which is then converted into the desired product by condensation with (2-methoxyphenyl)piperazine dihydrochloride (IV), either by means of Na2CO3/NaI or with K2CO3 in refluxing 5-methyl-2-hexanone.

参考文献No.	596124
标题:	Radiochemical labelling of the dopamine D-3 receptor ligand RGH-1756
作者:	Langer, O.; et al.
来源:	J Label Compd Radiopharm 2000,43(11),1069

合成路线图解说明: By methylation of the phenolic precursor (I) with 11C labeled methyl triflate and NaOH in acetone.