【药物名称】
化学结构式(Chemical Structure):
参考文献No.479728
标题:17alpha-Alkyl- or 17alpha-substituted benzyl-17beta-estradiols: A new family of estrone-sulfatase inhibitors
作者:Poirier, D.; Boivin, R.P.
来源:Bioorg Med Chem Lett 1998,8(14),1891
合成路线图解说明:

Grignard reagent (II) was prepared from 3-bromobenzyl halide (I) in Et2O at 0 C, and subsequently added to estrone (III) to provide the target carbinol.

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