KN-734, CT-052923, CT-52923-药物合成数据库

【药物名称】KN-734, CT-052923, CT-52923

化学结构式(Chemical Structure):

参考文献No.	36282
标题:	Nitrogenous heterocyclic cpds
作者:	Matsuno, K.; Ichimura, M.; Nomoto, Y.; Fujiwara, S.; Ide, S.; Tsukuda, E.; Irie, J.; Oda, S. (Kyowa Hakko Kogyo Co., Ltd.)
来源:	EP 0882717; WO 9814431

合成路线图解说明: The title thiourea derivative was prepared by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 1,3-benzodioxol-5-ylmethyl isothiocyanate (II) in refluxing ethanol.

合成路线图解说明: The title urea derivative was synthesized by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 4-bromophenyl isocyanate (II) in refluxing ethanol.

参考文献No.	689161
标题:	Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline deri
作者:	Matsuno, K.; Nakajima, T.; Ichimura, M.; Giese, N.A.; Yu, J.C.; Lokker, N.A.; Ushiki, J.; Ide, S.-i.; Oda, S.; Nomoto, Y.
来源:	J Med Chem 2002,45(20),4513

合成路线图解说明: The title thiourea derivative was prepared by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 1,3-benzodioxol-5-ylmethyl isothiocyanate (II) in refluxing ethanol.