【药物名称】
化学结构式(Chemical Structure):
参考文献No.464826
标题:Potent antimitotic and cell growth inhibitory properties of substituted chalcones
作者:Ducki, S.; Forrest, R.; Hadfield, J.A.; Kendall, A.; Lawrence, N.J.; McGown, A.T.; Rennison, D.
来源:Bioorg Med Chem Lett 1998,8(9),1051
合成路线图解说明:

Addition of ethylmagnesium bromide to 3,4,5-trimethoxybenzaldehyde (I) gave secondary alcohol (II), which was converted into ketone (III) by Swern oxidation with DMSO and oxalyl chloride. Piperidinium acetate-catalyzed aldol condensation of propiophenone (III) with 3-hydroxy-4-methoxybenzaldehyde (IV), with water removal over 4 ?molecular sieves, gave the corresponding chalcone, obtained as a mixture of geometric isomers, from which the major E-isomer was separated by column chromatography.

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