【药物名称】GYKI-16638
化学结构式(Chemical Structure):
参考文献No.39644
标题:Novel antiarrhythmic cpds.
作者:Berzsenyi, P.; Druga, A.; P醫falusi, M.; Varga, I.; Rettegi, T.; Barlocco, D.; Moravcsik, I.; M醫yus, P.; Papp, G.; Varr? A.; Cignarella, G.; Simay, A. (Albert Szent-Gy鰎gyi Medical University ; Gyogyszerkutato Intezet Kft.)
来源:WO 9929655
合成路线图解说明:

Amine (I) was alkylated with 4-nitrophenethyl bromide (II) in refluxing isopropanol to yield the tertiary amine (III). Hydrogenation of the nitro group of (III) employing Pd/C afforded aniline (IV). Subsequent condensation of (IV) with methanesulfonyl chloride in the presence of Et3N produced the corresponding sulfonamide. The title compound was finally isolated as the hydrochloride salt.

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