【药物名称】MRS-2179
化学结构式(Chemical Structure):
参考文献No.462752
标题:Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors
作者:Camaioni, E.; Boyer, J.L.; Mohanram, A.; Harden, T.K.; Jacobson, K.A.
来源:J Med Chem 1998,41(1),183-190
合成路线图解说明:

2'-Deoxyadenosine (I) was protected as the diacetate (II) on treatment with acetic anhydride and a catalytic amount of dimethylaminopyridine. Then, reaction with an excess of isopentyl nitrite and diiodomethane under illumination of a tungsten lamp provided iodide (III). Subsequent treatment with ethanolic methylamine effected both deacetylation and substitution of iodide to give 2'-deoxy-N6-methyladenosine (IV). Finally, this was treated with phosphoryl chloride and Proton Sponge(R) in trimethyl phosphate at 0 C, followed by quenching with triethyl ammonium bicarbonate buffer to yield the target bisphosphate.

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