CZ-48-药物合成数据库

【药物名称】CZ-48

化学结构式(Chemical Structure):

参考文献No.	37440
标题:	Derivs. of camptothecin for use in treating cancer
作者:	Ciovanella, B.C.; Zhisong, C. (The Stehlin Foundation for Cancer Research)
来源:	EP 0879236; WO 9728165

合成路线图解说明: By esterification of camptothecin (I) with propionic anhydride in pyridine.

参考文献No.	458743
标题:	Alkyl esters of camptothecin and 9-nitrocamptothecin: Synthesis, in vitro pharmacokinetics, toxicity, and antitumor activity
作者:	Cao, Z.; Harris, N.V.; Kozielski, A.; Vardeman, D.; Stehlin, J.S.; Giovanella, B.
来源:	J Med Chem 1998,41(1),31

合成路线图解说明: By esterification of camptothecin (I) with propionic anhydride in pyridine.