【药物名称】AGZ-1067, AGI-1067
化学结构式(Chemical Structure):
参考文献No.54391
标题:Cpds. and methods for the inhibition of the expression of VCAM-1
作者:Medford, R.M.; Meng, C.Q.; Hoong, L.K.; Somers, P.K. (AtheroGenics, Inc.)
来源:JP 2002503227; US 6147250; WO 9851662
合成路线图解说明:

Esterification of probucol (I) with succinic anhydride (II) in the presence of NaH afforded the title monosuccinate ester, which was separated from the unreacted probucol (I) and the corresponding disuccinate ester by column chromatography. Esterification of (I) was also reported in the presence of other bases, such as potassium tert-butoxide, KOH, DMAP and DABCO.

参考文献No.54393
标题:Process for preparing probucol derivs.
作者:Jass, P.A.
来源:US 6323359
合成路线图解说明:

Esterification of probucol (I) with succinic anhydride (II) in the presence of NaH afforded the title monosuccinate ester, which was separated from the unreacted probucol (I) and the corresponding disuccinate ester by column chromatography. Esterification of (I) was also reported in the presence of other bases, such as potassium tert-butoxide, KOH, DMAP and DABCO.

参考文献No.696970
标题:Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis
作者:Meng, C.Q.; Somers, P.K.; Rachita, C.L.; Holt, L.A.; Hoong, L.K.; Zehng, X.S.; Simpson, J.E.; Hill, R.R.; Olliff, L.K.; Kunsch, C.; Sundell, C.L.; Parthasarathy, S.; Saxena, U.; Sikorski, J.A.; Wasserman, M.A.
来源:Bioorg Med Chem Lett 2002,12(18),2545
合成路线图解说明:

Esterification of probucol (I) with succinic anhydride (II) in the presence of NaH afforded the title monosuccinate ester, which was separated from the unreacted probucol (I) and the corresponding disuccinate ester by column chromatography. Esterification of (I) was also reported in the presence of other bases, such as potassium tert-butoxide, KOH, DMAP and DABCO.

参考文献No.733781
标题:AGI-1067
作者:Sorbera, L.A.; Casta馿r, J.
来源:Drugs Fut 2003,28(5),421
合成路线图解说明:

Esterification of probucol (I) with succinic anhydride (II) in the presence of NaH afforded the title monosuccinate ester, which was separated from the unreacted probucol (I) and the corresponding disuccinate ester by column chromatography. Esterification of (I) was also reported in the presence of other bases, such as potassium tert-butoxide, KOH, DMAP and DABCO.

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