NS-1652-药物合成数据库

【药物名称】NS-1652

化学结构式(Chemical Structure):

参考文献No.	35192
标题:	Phenyl derivs. containing an acidic group, their preparation and their use as chloridic channel blockers
作者:	Christophersen, P.; Pedersen, O. (NeuroSearch A/S)
来源:	EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879

合成路线图解说明: The title urea derivative was obtained by condensation of 3-(trifluoromethyl)phenyl isocyanate (I) with anthranilic acid (II).

合成路线图解说明: The target compound can be obtained by condensation of 3-trifluoromethylphenyl isocyanate (I) with 5-(2-amino-5-bromophenyl)tetrazole in toluene.

参考文献No.	574808
标题:	Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid
作者:	Baures, P.W.; Oza, V.B.; Peterson, S.A.; Kelly, J.W.
来源:	Bioorg Med Chem 2000,7(7),1339

合成路线图解说明: The title urea derivative was obtained by condensation of 3-(trifluoromethyl)phenyl isocyanate (I) with anthranilic acid (II).