【药物名称】G-20000, L-39
化学结构式(Chemical Structure):
参考文献No.545916
标题:17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives, novel steroidal inhibitors of human cytochrome C17,20-lyase (P45017alpha)
作者:Ling, Y.; Li, J.S.; Liu, Y.; Kato, K.; Klus, G.T.; Brodie, A.
来源:J Med Chem 1997,40(20),3297
合成路线图解说明:

Claisen condensation of 3-beta-acetyloxypregna-5,16-dien-20-one (I) with ethyl formate in the presence of NaOMe in pyridine, with simultaneous deacetylation, provided the corresponding 21-formyl derivative (II). Subsequent treatment of (II) with hydroxylamine yielded isoxazole (III) as the only regioisomer. Finally, Oppenauer oxidation of (III) with cyclohexanone and aluminum isopropoxide gave rise to the target alpha,beta-unsaturated ketone.

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