【药物名称】FR-193879
化学结构式(Chemical Structure):
参考文献No.34046
标题:New cephem cpds. and pharmaceutical use thereof
作者:Yoshida, Y.; Okuda, S.; Sasaki, H.; Matsuda, K.; Takasugi, H. (Fujisawa Pharmaceutical Co., Ltd.)
来源:EP 0882052; JP 2000505432; WO 9729111
合成路线图解说明:

The reaction of 2-(2-sulfanylthiazol-4-yl)acetic acid ethyl ester (I) with ammonia and ammonium chloride gives the corresponding acetamide (II), which is condensed with the cephem methanesulfonate (III) by means of potassium tert-butoxide in dimethoxyethane to yield the diphenylmethyl ester (IV) of the target compound, which is finally hydrolyzed with trifluoroacetic acid and anisole.

合成路线图解说明:

In an alternative method, benzhydryl ester (V) was cleaved with trifluoroacetic acid to give carboxylic acid (VI). After protection of (VI) by means of trimethylsilyl acetamide, the triflate group was displaced by the potassium salt of mercapto thiadiazole (III) to furnish the title compound.

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