| 参考文献No. | 33808 |
| 标题: | Lactone derivs. of 17beta-carboxy, carbothio and amide androstane derivs. |
| 作者: | Biggadike, K.; Procopiou, P.A. (Glaxo Wellcome plc) |
| 来源: | JP 1999501675; US 6197761; WO 9724365 |
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| 合成路线图解说明: Treatment of carboxylic acid (I) with diethyl chlorophosphate (II) in the presence of Et3N furnished the corresponding mixed anhydride (III). This was then condensed with the sodium salt of alpha-mercapto-gamma-butyrolactone (IV) to produce the title thioester. |
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| 合成路线图解说明: The title compound was prepared by condensation of the carbothioic acid (I) with alpha-bromo-gamma-butyrolactone (II) in the presence of K2CO3 in DMF. |