【药物名称】Estrone 3-oleate, Oleoyl-estrone
化学结构式(Chemical Structure):
参考文献No.33382
标题:Fatty-acid monoesters of estrogens for the treatment of obesity and/or overweight
作者:Alemany, M. (Laboratorios Salvat SA)
来源:EP 0771817; US 5798348
合成路线图解说明:

Oleoyl-estrone can be obtained by direct condensation of commercially available estrone (I) and oleoyl chloride (II) in anhydrous pyridine at 40 C.

参考文献No.668981
标题:Rats receiving the slimming agent oleoyl-estrone in liposomes (Merlin-2) decrease food intake but maintain thermogenesis
作者:Sanchis, D.; Balada, F.; Pic? C.; Grasa, M.M.; Virgili, J.; Farrerons, C.; Palou, A.; Fern醤dez-L髉ez, J.A.; Remesar, X.; Alemany, M.
来源:Arch Physiol Biochem 1997,105(7),663
合成路线图解说明:

Oleoyl-estrone can be obtained by direct condensation of commercially available estrone (I) and oleoyl chloride (II) in anhydrous pyridine at 40 C.

参考文献No.689000
标题:Oleoyl-Estrone
作者:del Fresno, M.; Cullell-Young, M.
来源:Drugs Fut 2002,27(7),648
合成路线图解说明:

Oleoyl-estrone can be obtained by direct condensation of commercially available estrone (I) and oleoyl chloride (II) in anhydrous pyridine at 40 C.

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