Talaporfin sodium, Mono-L-aspartyl chlorin e6, LS-11, ME-2906, NPe6, Laserphyrin-药物合成数据库

【药物名称】Talaporfin sodium, Mono-L-aspartyl chlorin e6, LS-11, ME-2906, NPe6, Laserphyrin

化学结构式(Chemical Structure):

参考文献No.	25794
标题:	Tetrapyrrole carboxylic acid derivs. for diagnosis and/or therapy of arthritis
作者:	Aizawa, K.; Kuroiwa, Y. (Nippon Petrochemicals Co., Ltd.)
来源:	EP 0629409; US 5430051

合成路线图解说明: Coupling of chlorin e6 (I) with L-aspartic acid di-t-butyl ester (II) in the presence of DCC gave rise to amide (III). The ester groups were then hydrolyzed using a 1 M solution of KOH.

参考文献No.	545527
标题:	The structures of mono-L-aspartyl chlorin e6 and its related compounds
作者:	Gomi, S.; et al.
来源:	Heterocycles 1998,48(11),2231

合成路线图解说明: Coupling of chlorin e6 (I) with L-aspartic acid di-t-butyl ester (II) in the presence of DCC gave rise to amide (III). The ester groups were then hydrolyzed using a 1 M solution of KOH.