【药物名称】Fadolmidine hydrochloride, Radolmidine hydrochloride, MPV-2426
化学结构式(Chemical Structure):
参考文献No.33091
标题:Imidazole derivs. having affinity for alpha2 receptors activity
作者:Karjalainen, A.; Huhtala, P.; Savola, J.-M.; Wurster, S.; Eloranta, M.; Savola, M.; Saxlund, R.; Cockcroft, V. (Orion Corporation)
来源:EP 0888309; JP 2000507914; WO 9712874
合成路线图解说明:

Reductive coupling of 6-methoxy-1-indanone (I) with 1-benzylimidazole-5-carbaldehyde (II) using TiCl4 and Zn in boiling THF afforded the indanylidenemethyl imidazole (III). Hydrogenation of the double bond of (III) and simultaneous debenzylation in the presence of Pd/C provided the indanylmethyl derivative (IV). The methyl ether group of (IV) was finally cleaved by refluxing in concentrated HBr, and the title compound was isolated after conversion to the hydrochloride salt.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us