The reduction of indazole-5-carboxylic acid (I) with diisobutylaluminum hydride (DIBAL) in dichloromethane gives the expected methanol (II), which by reaction with mesyl chloride and ethyldiisopropylamine in DMF is converted into 5-(chloromethyl)indazole (III). Finally, this compound is condensed with (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxyperhydro-1,3-diazepin-2-one (IV) by means of NaH in DMF.

The radical bromination of 5-methylidazole (V) by means of N-bromosuccinimide (NBS) and benzoyl peroxide in refluxing CCl4 gives the corresponding bromomethyl derivative (VI), which is then condensed with the diazepine (IV) as before.