【药物名称】ISA-13-1
化学结构式(Chemical Structure):
参考文献No.555339
标题:Synthesis and preclinical pharmacology of 2-(2-aminopyrimidino) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1) - A novel biphosphonate
作者:Cohen, H.; Alferiev, I.S.; Monkkonen, J.; Seibel, M.J.; Pinto, T.; Ezra, A.; Solomon, V.; Stepensky, D.; Sagi, H.; Ornoy, A.; Patlas, N.; Hagele, G.; Hoffman, A.; Breuer, E.; Golomb, G.
来源:Pharm Res 1999,16(9),1399
合成路线图解说明:

The title compound was synthesized by nucleophilic addition of 2-aminopyrimidine (I) to vinylidene-1,1-bisphosphonic acid (II).

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