2-Iodoadenosine (I) was protected as the ketal (II) on treatment with p-toluenesulfonic in an excess of acetone. This compound was oxidized to the acid (III) with potassium permanganate in aqueous alkaline solution. Deprotection of the ketal was accomplished on heating in 50% formic acid to give IV, which was then esterified in ethanolic solution by means of dropwise addition of thionyl chloride. The resulting ethyl ester (V) was dissolved in liquid ethylamine to afford amide (VI). Finally, VI was coupled with 1-phenyl-2-propyn-1-ol (VII) in the presence of triethylamine and a trace of bis(triphenylphosphine)palladium dichloride and cuprous iodide, to yield the title compound.

2-Iodoadenosine (I) was protected as the ketal (II) on treatment with p-toluenesulfonic in an excess of acetone. This compound was oxidized to the acid (III) with potassium permanganate in aqueous alkaline solution. Deprotection of the ketal was accomplished on heating in 50% formic acid to give IV, which was then esterified in ethanolic solution by means of dropwise addition of thionyl chloride. The resulting ethyl ester (V) was dissolved in liquid ethylamine to afford amide (VI). Finally, VI was coupled with 1-phenyl-2-propyn-1-ol (VII) in the presence of triethylamine and a trace of bis(triphenylphosphine)palladium dichloride and cuprous iodide, to yield the title compound.