NS-8-药物合成数据库

【药物名称】NS-8

化学结构式(Chemical Structure):

参考文献No.	32071
标题:	Pyrrole derivs. and medicinal compsn.
作者:	Tsuda, M.; Tanaka, M.; Nakamura, A. (Nippon Shinyaku Co., Ltd.)
来源:	US 5998459; WO 9640634

合成路线图解说明: Treatment of 2-fluorophenylglycine (I) with Ac2O and pyridine at 150 C produced 1-(2-fluorophenyl)-1-acetamido-2-propanone (II). This was subsequently condensed with malononitrile yielding the title pyrrole derivative.

参考文献No.	601216
标题:	Studies on potassium channel openers: Synthesis and pharmacological properties of novel pyrrole derivatives
作者:	Tsuda, M.; et al.
来源:	20th Symp Med Chem (Dec 6 2000, Tokyo) 2000,Abst 2P-24

合成路线图解说明: The partial hydrolysis of malonodinitrile (I) with HCl in ethanol gives 2-cyanoacetamide (II), which is treated with ammonia in ethanol to yield 3,3-diaminopropenenitrile (III). Finally, this compound is cyclized with 2-bromo-1-(2-fluorophenyl)-1-propanone (IV) by means of TEA in ethanol.