4-Amino-1-benzylpiperidine (II) was acylated with 5-methyl-2-nitrobenzoyl chloride (I) to afford the ortho-nitrobenzamide (III), which was reduced to the amino derivative (IV) by catalytic hydrogenation in the presence of Pd/C. Treatment of (IV) with ethyl chloroformate produced the bis-carbamate (V) with concomitant cleavage of the N-benzyl group. This was cyclized to the dioxoquinazoline (VI) upon treatment with KOH in refluxing EtOH. After N-methylation employing iodomethane and NaH in DMF, hydrolysis of the carbamate group with concentrated HBr yielded the piperidinylquinazoline (VIII). This was then condensed with 2,4-dichloro-6,7-diethoxyquinazoline (IX) to furnish adduct (X). Finally, displacement of the remaining chlorine of (X) with morpholine (XI) in hot NMP gave rise to the title compound.

4-Amino-1-benzylpiperidine (II) was acylated with 5-methyl-2-nitrobenzoyl chloride (I) to afford the ortho-nitrobenzamide (III), which was reduced to the amino derivative (IV) by catalytic hydrogenation in the presence of Pd/C. Treatment of (IV) with ethyl chloroformate produced the bis-carbamate (V) with concomitant cleavage of the N-benzyl group. This was cyclized to the dioxoquinazoline (VI) upon treatment with KOH in refluxing EtOH. After N-methylation employing iodomethane and NaH in DMF, hydrolysis of the carbamate group with concentrated HBr yielded the piperidinylquinazoline (VIII). This was then condensed with 2,4-dichloro-6,7-diethoxyquinazoline (IX) to furnish adduct (X). Finally, displacement of the remaining chlorine of (X) with morpholine (XI) in hot NMP gave rise to the title compound.