RSD-992-药物合成数据库

【药物名称】RSD-992

化学结构式(Chemical Structure):

参考文献No.	43602
标题:	Serotonin ligands as pro-erectile cpds.
作者:	Hayes, E.S. (Cardiome Pharma Corp.)
来源:	WO 0028993

合成路线图解说明: 2-(2-Naphthyl)acetic acid (I) is activated as the corresponding acid chloride (II) upon refluxing with SOCl2. Subsequent condensation of acid chloride (II) with N-methyl piperazine (III) affords the title amide.

参考文献No.	55755
标题:	Aroylpiperazines for modulating sexual activity
作者:	Zolotoy, A.B.; Hayes, E.S. (Cardiome Pharma Corp.)
来源:	WO 9902159

合成路线图解说明: 2-(2-Naphthyl)acetic acid (I) is activated as the corresponding acid chloride (II) upon refluxing with SOCl2. Subsequent condensation of acid chloride (II) with N-methyl piperazine (III) affords the title amide.