IDR-16084, GYKI-16084, Uroflux-药物合成数据库

【药物名称】IDR-16084, GYKI-16084, Uroflux

化学结构式(Chemical Structure):

参考文献No.	40880
标题:	3(2H)-Pyridazinone derivs. and pharmaceutical compsns. containing these cpds.
作者:	Horv醫h, E.; Simay, A.; Tomori, ?; Druga, A.; Kasztreiner, E.; Tilahun, Y.; Makk, N.; Kir醠y, I.; Kos醨y, J.; Papp, ?; Varga, M.; Z醨a, E.; Karim, M.; Sebesty閚, L.; Varga, I.; Bidl? M.; Horv醫h, K.; M醫h? I.; et al. (Gyogyszerkutato Intezet Kft.)
来源:	WO 9638441

合成路线图解说明: The enantiomerically pure benzodioxane derivative (VIII) was obtained in a straightforward route including five steps starting from pyrocatechin (I). Racemic (VI) was then resolved by means of crystallization with (-)-O,O'-dibenzoyl-L-tartaric acid.

合成路线图解说明: The pyridazinone intermediate (XII) was prepared from dihydroxypyridazine (IX) in three synthetic steps.

合成路线图解说明: Finally, N-alkylation of the potassium salt of (XII) with the base form of (VIII) was performed in dimethyl sulfoxide to afford GYKI-16084.

参考文献No.	553380
标题:	GYKI-16084
作者:	M醫yus, P.
来源:	Drugs Fut 1999,24(10),1072

合成路线图解说明: The enantiomerically pure benzodioxane derivative (VIII) was obtained in a straightforward route including five steps starting from pyrocatechin (I). Racemic (VI) was then resolved by means of crystallization with (-)-O,O'-dibenzoyl-L-tartaric acid.

合成路线图解说明: The pyridazinone intermediate (XII) was prepared from dihydroxypyridazine (IX) in three synthetic steps.

合成路线图解说明: Finally, N-alkylation of the potassium salt of (XII) with the base form of (VIII) was performed in dimethyl sulfoxide to afford GYKI-16084.