ML-10375-药物合成数据库

【药物名称】ML-10375

化学结构式(Chemical Structure):

参考文献No.	29040
标题:	Esters of 4-amino-5-chloro-2-methoxybenzoic acid, process for their preparation and pharmaceutical compsns. containing them
作者:	Langlois, M.; Guzzi, U.; Cecchi, R.; Croci, T. (Midy SpA)
来源:	EP 0683161

合成路线图解说明: Reaction of 4-amino-5-chloro-2-methoxybenzoic acid (I) with 1,2-dibromoethane in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene afforded bromoethyl ester (II). This was then condensed with a mixture of cis and trans 3,5-dimethylpiperidines (III), and the resulting mixture of amines was finally separated by column chromatogaphy to provide the target cis compound.

参考文献No.	412393
标题:	New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors
作者:	Yang, D.; Soulier, J.-L.; Sicsic, S.; Mathe-Allainmat, M.; Bremont, B.; Croci, T.; Cardamone, R.; Aureggi, G.; Langlois, M.
来源:	J Med Chem 1997,40(4),608

合成路线图解说明: Reaction of 4-amino-5-chloro-2-methoxybenzoic acid (I) with 1,2-dibromoethane in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene afforded bromoethyl ester (II). This was then condensed with a mixture of cis and trans 3,5-dimethylpiperidines (III), and the resulting mixture of amines was finally separated by column chromatogaphy to provide the target cis compound.