【药物名称】KCB-328
化学结构式(Chemical Structure):
参考文献No.482613
标题:Synthesis and biological activity of KCB-328 and its analogues: Novel class III antiarrhythmic agents with little reverse frequency dependence
作者:Kim, D.-I.; Kim, H.Y.; Kwon, L.S.; Park, S.D.; Jeon, G.H.; Jung, K.Y.; Min, J.K.; Nam, W.H.; Lee, K.; Chung, Y.S.; Tanabe, S.; Kozono, T.
来源:Bioorg Med Chem Lett 1999,9(1),85
合成路线图解说明:

Alkylation of phenol (I) with 1,2-dibromoethane (II) in the presence of K2CO3 in DMF yielded bromoethyl ether (III), which was further, condensed with amine (IV) to afford tertiary amine (V). The nitro group of (V) was then reduced by either catalytic hydrogenation in the presence of Pd/C or by treatment with SnCl2 in aqueous HCl, and the resulting aniline (VI) was condensed with methanesulfonyl chloride in pyridine to give sulfonamide (VII). Finally, acid hydrolysis of the acetamido group provided the title compound.

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