Maribavir, Benzimidavir, GW-257406X, GW-1263, BW-1263W94, 1263W94-药物合成数据库

【药物名称】Maribavir, Benzimidavir, GW-257406X, GW-1263, BW-1263W94, 1263W94

化学结构式(Chemical Structure):

参考文献No.	28874
标题:	Therapeutic cpds
作者:	Chamberlain, S.D.; Koszalka, G.W. (Glaxo Wellcome plc)
来源:	EP 0769017; JP 1998502356; US 6077832; WO 9601833

合成路线图解说明: The condensation of 2-bromo-5,6-dichlorobenzimidazole (I) with 1,2,3,5-tetra-O-acetyl-L-ribofuranose (II) by means of N,O-bis(trimethylsilyl)acetamide (BTSA) in refluxing acetonitrile gives 2-bromo-5,6-dichloro-1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl) benzimidazole (III), which is then treated with an excess of isopropylamine in hot ethanol.

参考文献No.	414586
标题:	Benzimidavir
作者:	Graul, A.; Tracy, M.; Casta馿r, J.
来源:	Drugs Fut 1997,22(7),707

合成路线图解说明: The condensation of 2-bromo-5,6-dichlorobenzimidazole (I) with 1,2,3,5-tetra-O-acetyl-L-ribofuranose (II) by means of N,O-bis(trimethylsilyl)acetamide (BTSA) in refluxing acetonitrile gives 2-bromo-5,6-dichloro-1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl) benzimidazole (III), which is then treated with an excess of isopropylamine in hot ethanol.