【药物名称】Benextramine
化学结构式(Chemical Structure):
参考文献No.607184
标题:Molecular properties of the adrenergic alpha receptor. 2. Optimum covalent inhibition by two different prototypes of polyamine disulfides
作者:Melchiorre, C.; Yong, M.S.; Benfey, B.G.; Belleau, B.
来源:J Med Chem 1978,21(11),1126-32
合成路线图解说明:

N-(6-Aminohexyl)cysteamine (I), synthesized according to Wineman et al., is converted to the disulfide (II) by potassium ferricyanide oxidation. The substituent on the terminal nitrogens is introduced by condensation with the aromatic aldehyde (III) and subsequent reduction with NaBH4 of the intermediate Schiff base (IV).

参考文献No.800472
标题:Thiolethylation of amines with ethylene disulfide
作者:James, J.C.; Wineman, R.J.; Pomponi, A.M.; Gollis, M.H.
来源:J Org Chem 1962,274222-26
合成路线图解说明:

N-(6-Aminohexyl)cysteamine (I), synthesized according to Wineman et al., is converted to the disulfide (II) by potassium ferricyanide oxidation. The substituent on the terminal nitrogens is introduced by condensation with the aromatic aldehyde (III) and subsequent reduction with NaBH4 of the intermediate Schiff base (IV).

参考文献No.800474
标题:Benextramine
作者:Benfey, B.G.
来源:Drugs Fut 1981,6(12),751
合成路线图解说明:

N-(6-Aminohexyl)cysteamine (I), synthesized according to Wineman et al., is converted to the disulfide (II) by potassium ferricyanide oxidation. The substituent on the terminal nitrogens is introduced by condensation with the aromatic aldehyde (III) and subsequent reduction with NaBH4 of the intermediate Schiff base (IV).

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