Ro-25-6760-药物合成数据库

【药物名称】Ro-25-6760

化学结构式(Chemical Structure):

参考文献No.	28392
标题:	Vitamin D3 fluorinated analogs
作者:	Baggiolini, B.J.; Shiuey, S.-J.; Uskokovic, M.R. (F. Hoffmann-La Roche AG)
来源:	US 5451574; US 5753638

合成路线图解说明: Condensation of the lithium anion of alkyne (I) with hexafluoroacetone provided the tertiary alcohol (II). Subsequent deprotection of the silyl ether of (II) with tetrabutylammonium fluoride yielded alcohol (III), which was oxidized to ketone (IV) by means of pyridinium chlorochromate. Wittig condensation of (IV) with the ylide resulting from phosphine (V) and BuLi produced diene (VI). Finally, both silyl ethers of (VI) were cleaved with tetrabutylammonium fluoride to furnish the title compound.

参考文献No.	39670
标题:	Vitamin D3 fluorinated analogs
作者:	Uskokovic, M.R.; Baggiolini, E.G.; Shiuey, S.-J. (F. Hoffmann-La Roche AG)
来源:	EP 0580968

合成路线图解说明: Condensation of the lithium anion of alkyne (I) with hexafluoroacetone provided the tertiary alcohol (II). Subsequent deprotection of the silyl ether of (II) with tetrabutylammonium fluoride yielded alcohol (III), which was oxidized to ketone (IV) by means of pyridinium chlorochromate. Wittig condensation of (IV) with the ylide resulting from phosphine (V) and BuLi produced diene (VI). Finally, both silyl ethers of (VI) were cleaved with tetrabutylammonium fluoride to furnish the title compound.