【药物名称】Clevidipine, Clevelox
化学结构式(Chemical Structure):
参考文献No.27104
标题:Short-acting dihydropyridines
作者:Andersson, K.H.; Nordlander, M.; Westerlund, R.C. (AstraZeneca plc)
来源:EP 0726894; JP 1997504542; US 5856346; WO 9512578
合成路线图解说明:

Clevidipine is prepared by esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (I) with chloromethyl butyrate (II) by means of NaHCO3 in DMF at 80 oC (1) or refluxing acetonitrile (2).

参考文献No.66713
标题:New manufacturing process
作者:Mattson, A.; Svensson, C.; Th鰎nblom, K.; 謉man, C. (AstraZeneca AB)
来源:CA 2349195; EP 1133473; US 6350877; WO 0031035
合成路线图解说明:

Clevidipine is prepared by esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (I) with chloromethyl butyrate (II) by means of NaHCO3 in DMF at 80 oC (1) or refluxing acetonitrile (2).

参考文献No.783228
标题:Clevidipine
作者:Sorbera, L.A.; Casta馿r, J.
来源:Drugs Fut 2004,29(2),105
合成路线图解说明:

Clevidipine is prepared by esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (I) with chloromethyl butyrate (II) by means of NaHCO3 in DMF at 80 oC (1) or refluxing acetonitrile (2).

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