TAN-67-药物合成数据库

【药物名称】TAN-67

化学结构式(Chemical Structure):

参考文献No.	477817
标题:	Rational drug design and synthesis of a highly selective nonpeptide delt-opioid agonist, (4aS,12aR)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octrahydropyrido[3,4-b]acridine (TAN-67)
作者:	Nagase, H.; Kawai, K.; Hayakawa, J.; Wakita, H.; Mizusuna, A.; Matsuura, H.; Tajima, C.; Takezawa, Y.; Endoh, T.
来源:	Chem Pharm Bull 1998,46(11),1695

合成路线图解说明: The cyclization of perhydroisoquinoline (I) with o-amino-benzaldehyde (II) in the presence of methanesulfonic acid in refluxing EtOH gave the pyridoacridine (III). Subsequent cleavage of the methyl ether function using n-PrSH and tert-BuOK in boiling DMF provided the target phenol.

参考文献No.	558204
标题:	Rational drug design and synthesis of opioid delta-receptor selective nonpeptidic agonists - Optical resolution of (? TAN-67 and the pharmacological effect of each enantiomer
作者:	Fujii, H.; et al.
来源:	Symp Med Chem 1999,Abst 1P-21

合成路线图解说明: The cyclization of perhydroisoquinoline (I) with o-amino-benzaldehyde (II) in the presence of methanesulfonic acid in refluxing EtOH gave the pyridoacridine (III). Subsequent cleavage of the methyl ether function using n-PrSH and tert-BuOK in boiling DMF provided the target phenol.