【药物名称】Aspalatone, AAME, BK-111
化学结构式(Chemical Structure):
参考文献No.300669
标题:Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity
作者:Han, B.H.; Suh, D.-Y.; Yang, H.O.; Park, Y.-H.; Kang, Y.H.; Kim, Y.C.
来源:Arzneim-Forsch Drug Res 1994,44(10),1122-6
合成路线图解说明:

Acetylsalicylic (I) acid was refluxed in SOCl2 to give acetylsalicylyl chloride (II), which is condensed with maltol (III) by means of triethylamine in chloroform to afford aspalatone.

参考文献No.323775
标题:Aspalatone
作者:Han, B.H.
来源:Drugs Fut 1995,20(11),1109
合成路线图解说明:

Acetylsalicylic (I) acid was refluxed in SOCl2 to give acetylsalicylyl chloride (II), which is condensed with maltol (III) by means of triethylamine in chloroform to afford aspalatone.

参考文献No.801419
标题:The aspirin papers
作者:Underwood, M.J.; More, R.S.
来源:Brit Med J 1994,30871-2
合成路线图解说明:

Acetylsalicylic (I) acid was refluxed in SOCl2 to give acetylsalicylyl chloride (II), which is condensed with maltol (III) by means of triethylamine in chloroform to afford aspalatone.

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