【药物名称】Saussureamine A
化学结构式(Chemical Structure):
参考文献No.594384
标题:Absolute stereostructures and syntheses of saussureamines A, B, C, D and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots of Saussurea lappa
作者:Matsuda, H.; et al.
来源:Tetrahedron 2000,56(39),7763
合成路线图解说明:

By condensation of costunolide (I) (isolated from the dried roots of Chinese plant Saussurea lappa) with L-proline (II) by means of Et3N in refluxing ethanol.

合成路线图解说明:

By condensation of dehydrocostus lactone (I) (isolated from the dried roots of Chinese plant Saussurea lappa) with L-proline (II) by means of Et3N in refluxing ethanol.

合成路线图解说明:

By condensation of dehydrocostus lactone (I) (isolated from the dried roots of Chinese plant Saussurea lappa) with L-asparagine (II) by means of Et3N in refluxing ethanol.

合成路线图解说明:

The epoxidation of costunolide (I) (isolated from the dried roots of Chinese plant Saussurea lappa) with MCPBA followed by cyclization by means of BF3稥t2O gives a mixture of two furo-naphthalene derivatives that is separated by gel chromatography. The desired isomer (II) is finally condensed with L-proline (III) by means of Et3N in refluxing ethanol.

合成路线图解说明:

The epoxidation of costunolide (I) (isolated from the dried roots of Chinese plant Saussurea lappa) with MCPBA followed by cyclization by means of BF3稥t2O gives a mixture of two furo-naphthalene derivatives that is separated by gel chromatography. The desired isomer (II) is finally condensed with L-proline (III) by means of Et3N in refluxing ethanol.

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