Finrozole, MPV-2213ad-药物合成数据库

【药物名称】Finrozole, MPV-2213ad

化学结构式(Chemical Structure):

参考文献No.	24035
标题:	Cyanobenzyl heterocyclic aromatase-inhibiting cpds.
作者:	Karjalainen, A.J.; Sodervall, M.-L.; Kalapudas, A.M.; Pelkonen, R.O.; Laine, A.M.; Lammintausta, R.A.S.; Salonen, J.S. (Orion Corporation)
来源:	GB 2273704; JP 1996504424; US 5703109; US 5962495; WO 9413645

合成路线图解说明: MPV-2213ad was synthesized by condensation of 4-(1,2,4-triazol-1-ylmethyl)benzonitrile (I) with 2-(4-fluorophenyl)acetaldehyde (II) by means of butyllithium in THF. The two diastereomeric racemates are separated by flash chromatography.

参考文献No.	473991
标题:	MPV-2213ad
作者:	Silvestre, J.S.; Casta馿r, J.; Sorbera, L.A.
来源:	Drugs Fut 1998,23(10),1071-1074

合成路线图解说明: MPV-2213ad was synthesized by condensation of 4-(1,2,4-triazol-1-ylmethyl)benzonitrile (I) with 2-(4-fluorophenyl)acetaldehyde (II) by means of butyllithium in THF. The two diastereomeric racemates are separated by flash chromatography.