-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	23912
标题:	Process for the preparation of taxane derivs., novel taxanes so obtained and antitumour and antileukaemia compsns. containing same
作者:	Bourzat, J.-D.; Commer鏾n, A.; Deprez, D.; Pulicani, J.-P. (Aventis Pharma SA)
来源:	JP 1996503261; WO 9411547

合成路线图解说明: Conversion of paclitaxel (I) into 10-deacetoxypaclitaxel is achieved by electrolytic reduction or, alternatively, by deoxygenation, reduction and beta-elimination of the acetoxy group by means of SmI2 and HOAc.

参考文献No.	561802
标题:	A one-step synthesis of a deuterated paclitaxel analogue: 10-Deacetoxy-(10alpha-2H)paclitaxel
作者:	Dutta, D.; Hadd, H.; Vander Velde, D.G.; Georg, G.I.
来源:	Bioorg Med Chem Lett 1999,9(23),3277

合成路线图解说明: Conversion of paclitaxel (I) into 10-deacetoxypaclitaxel is achieved by electrolytic reduction or, alternatively, by deoxygenation, reduction and beta-elimination of the acetoxy group by means of SmI2 and HOAc.