RU-24213-药物合成数据库

【药物名称】RU-24213

化学结构式(Chemical Structure):

参考文献No.	800432
标题:	Synthesis of study of the dopaminergic activity of di(phenylethyl)amine derivatives
作者:	Nedelec, L.; et al.
来源:	Eur J Med Chem - Chim Ther 1978,13(6),553-556

合成路线图解说明: The reaction of 3-methoxyphenylethylamine (I) with phenylethyl bromide (II) in refluxing triethylamine gives 3-methoxy-N-(phenylethyl)phenylethylamine (III), which is alkylated with 1-iodopropane by means of K2CO3 in refluxing acetone yielding 3-methoxy-N-propyl-N-(phenylethyl)phenylethylamine (IV). Finally, this compound is demethylated by treatment with refluxing aqueous 48% HBr and formation of the HCl salt with hydrochloric acid.

参考文献No.	800433
标题:	RU-24213
作者:	Serradell, M.N.; Casta馿r, J.; Blancafort, P.; Owen, R.T.
来源:	Drugs Fut 1981,6(4),237

合成路线图解说明: The reaction of 3-methoxyphenylethylamine (I) with phenylethyl bromide (II) in refluxing triethylamine gives 3-methoxy-N-(phenylethyl)phenylethylamine (III), which is alkylated with 1-iodopropane by means of K2CO3 in refluxing acetone yielding 3-methoxy-N-propyl-N-(phenylethyl)phenylethylamine (IV). Finally, this compound is demethylated by treatment with refluxing aqueous 48% HBr and formation of the HCl salt with hydrochloric acid.