【药物名称】TZA-2237
化学结构式(Chemical Structure):
参考文献No.23552
标题:Novel 7-substd. oxa- or azasteroid cpd.
作者:Koizumi, N.; Takegawa, S.; Iwashita, S.; Kawachi, T.; Inoue, F.; Honma, S.; Takahashi, H.; Mieda, M.; Ueda, K.; Shibata, K. (Teikoku Hormone Manufacturing Co., Ltd.)
来源:EP 0663402; JP 1994508897; US 5539127; WO 9407908
合成路线图解说明:

Treatment of D-homo-17-oxaandrosta-1,4,6-triene-3,17a-dione (I) with refluxing thioacetic acid (II) yields either 7-alpha-(acetylthio) derivative (III) or 1alpha,7alpha-bis(acetylthio) derivative (IV). The desired product can then be obtained either by treatment of (III) with NaOH in THF or by reaction of (IV) with sodium methylate in methanol.

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