Elisartan potassium, HN-65021-药物合成数据库

【药物名称】Elisartan potassium, HN-65021

化学结构式(Chemical Structure):

参考文献No.	23683
标题:	Acylals of imidazole-5-carboxylic acid derivs., and their use as angiotensin (II) inhibitors
作者:	Binder, D.; Weinberger, J.
来源:	EP 0535420; US 5298519

合成路线图解说明: The esterification of 2-butyl-4-chloro-1H-imidazole-5-carboxylic acid (I) with 1-chloroethyl ethyl carbonate (II) by means of sodium silanolate in HMPT gives the corresponding ester (III), which is condensed with 5-[4'-(bromomethyl)biphenyl-2-yl]-1-(triphenylmethyl)tetrazole (IV) by means of K2CO3 in hot DMF, yielding the tritylated final product (V). Finally, this compound is deprotected in refluxing methanol.

参考文献No.	341994
标题:	Elisartan Potassium
作者:	Mealy, N.; Casta馿r, J.
来源:	Drugs Fut 1996,21(2),139

合成路线图解说明: The esterification of 2-butyl-4-chloro-1H-imidazole-5-carboxylic acid (I) with 1-chloroethyl ethyl carbonate (II) by means of sodium silanolate in HMPT gives the corresponding ester (III), which is condensed with 5-[4'-(bromomethyl)biphenyl-2-yl]-1-(triphenylmethyl)tetrazole (IV) by means of K2CO3 in hot DMF, yielding the tritylated final product (V). Finally, this compound is deprotected in refluxing methanol.