Tetrindol, Tetrindole, Tetrindol-药物合成数据库

【药物名称】Tetrindol, Tetrindole, Tetrindol

化学结构式(Chemical Structure):

参考文献No.	435685
标题:	Tetrindole
作者:	Glushkov, R.G.; Mashkovsky, M.D.; Andrejeva, N.I.
来源:	Drugs Fut 1997,22(12),1333

合成路线图解说明: The reaction of 6-cyclohexyl-3,4-dihydro-2H-carbazol-1-one (I) with 2-dibenzylaminoethyl chloride by means of phase transfer catalysis using benzyltriethylammonium chloride and sodium hydroxide in chlorobenzene gives 6-cyclohexyl-9-[2-(dibenzylamino)ethyl-3,4-dihydro-2H-carbazol-1-one (II), which is reduced with H2 over palladium bis(acetonylacetonate) and carbon to give tetrindol.

参考文献No.	452790
标题:	Design of new synthetic drugs: State of the art and prospects
作者:	Glushkov, R.G.
来源:	Vestn Russ Acad Med Sci 1994,1131-5

合成路线图解说明: The reaction of 6-cyclohexyl-3,4-dihydro-2H-carbazol-1-one (I) with 2-dibenzylaminoethyl chloride by means of phase transfer catalysis using benzyltriethylammonium chloride and sodium hydroxide in chlorobenzene gives 6-cyclohexyl-9-[2-(dibenzylamino)ethyl-3,4-dihydro-2H-carbazol-1-one (II), which is reduced with H2 over palladium bis(acetonylacetonate) and carbon to give tetrindol.