【药物名称】
化学结构式(Chemical Structure):
参考文献No.604692
标题:Phosphonates and thiophosphonates as sulfate surrogates: Synthesis of estrone 3-methylthiophosphonate a potent inhibitor of estrone sulfatase
作者:Reed, M.J.; Potter, B.V.L.; Purohit, A.; Howarth, N.M.; Cooper, G.; Duncan, L.J.
来源:Bioorg Med Chem Lett 1993,3(2),313-318
合成路线图解说明:

By esterification of 5,6,7,8-tetrahydronaphthalen-2-ol (I) with chlorosulfonamide (II) and NaH in DMF.

合成路线图解说明:

By esterification of estrone (I) with chlosulfonamide (II) and NaH in DMF.

参考文献No.803835
标题:Steroid sulphatase inhibitors: a new endocrine therapy
作者:Potter, B.V.L.; Howarth, N.M.; Purohit, A.; Reed, M.J.
来源:Drugs Fut 1994,19(7),673
合成路线图解说明:

By esterification of 5,6,7,8-tetrahydronaphthalen-2-ol (I) with chlorosulfonamide (II) and NaH in DMF.

合成路线图解说明:

By esterification of estrone (I) with chlosulfonamide (II) and NaH in DMF.

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