【药物名称】K-12
化学结构式(Chemical Structure):
参考文献No.557404
标题:Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A new class of anti-HIV agents
作者:Hagihara, M.; Kashiwase, H.; Katsube, T.; Kimura, T.; Komai, T.; Momota, K.; Ohmine, T.; Nishigaki, T.; Kimura, S.; Shimada, K.
来源:Bioorg Med Chem Lett 1999,9(21),3063
合成路线图解说明:

By the usual method of synthesis of fluoroquinolones: By condensation of 8-(difluoromethoxy)-6,7-difluoro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (I) with 1-(2-pyrimidinyl)piperazine (II) in pyridine.

合成路线图解说明:

By the usual method of synthesis of fluoroquinolones: By condensation of 8-(difluoromethoxy)-1-ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (I) with 1-(2-methoxyphenyl)piperazine (II) in pyridine.

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