【药物名称】FY-609, HSR-609
化学结构式(Chemical Structure):
参考文献No.21633
标题:Amphoteric tricyclic compounds as antihistaminic and antiallergic agents
作者:Ito, Y.; Kato, H.; Yasuda, S.; Kado, N.; Iwasaki, N.; Nishino, H.; Takeshita, M. (Hokuriku Seiyaku Co., Ltd.)
来源:EP 0556813; JP 1994192263; US 5334594
合成路线图解说明:

HSR-609 is obtained as shown in Scheme 20067601a: Tricyclic compound (II), derived from (I) by known methods, is converted to piperidine derivative (III) by Grignard reaction and dehydration. The reaction of (III) with ClCO2Et and KOH affords (IV). Michael reaction and hydrolysis of (IV) give HSR-609.

参考文献No.300666
标题:Amphoteric drugs. III. Synthesis and antiallergic activity of 3-[(5,11-dihydro[1]benzoxepino[4,3-b]pyridin-11-ylidene)piperidino] propionic acid derivatives and related compounds
作者:Iwasaki, N.; Ohashi, T.; Musoh, K.; Nishino, H.; Kado, N.; Yasuda, S.; Kato, H.; Ito, Y.
来源:J Med Chem 1995,38(3),496-507
合成路线图解说明:

HSR-609 is obtained as shown in Scheme 20067601a: Tricyclic compound (II), derived from (I) by known methods, is converted to piperidine derivative (III) by Grignard reaction and dehydration. The reaction of (III) with ClCO2Et and KOH affords (IV). Michael reaction and hydrolysis of (IV) give HSR-609.

参考文献No.453398
标题:HSR-609
作者:Suzuki, T.; Kato, H.; Nagata, O.; Inomata, N.; Ohashi, T.
来源:Drugs Fut 1998,23(4),379
合成路线图解说明:

HSR-609 is obtained as shown in Scheme 20067601a: Tricyclic compound (II), derived from (I) by known methods, is converted to piperidine derivative (III) by Grignard reaction and dehydration. The reaction of (III) with ClCO2Et and KOH affords (IV). Michael reaction and hydrolysis of (IV) give HSR-609.

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