【药物名称】MDL-101002
化学结构式(Chemical Structure):
参考文献No.20270
标题:Cyclic nitrones, their preparation and pharmaceutical compsns. containing them
作者:Carr, A.A.; Thomas, C.E.; Bernotas, R.C.; Ku, G. (Merrell Pharmaceuticals, Inc.)
来源:EP 0532027; US 5292746
合成路线图解说明:

Cyclization of N-formyl-alpha,alpha-dimethyl-b-phenethylamine (I) with phosphorous pentoxide in refluxing toluene led to isoquinoline (II), which was oxidized with 3-chloroperbenzoic acid (III) in dichloromethane at 0 C to give oxaziridine (IV). Finally, oxazirine (IV) was rearranged with sulfuric acid in aqueous methanol at room temperature to afford the target N-oxide.

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