YM-511-药物合成数据库

【药物名称】YM-511

化学结构式(Chemical Structure):

参考文献No.	20367
标题:	Triazolylated tertiary amine cpds. or salts thereof
作者:	Okada, M.; Kawaminami, E.; Yoden, T.; Kudo, M.; Isomura, Y. (Yamanouchi Pharmaceutical Co., Ltd.)
来源:	EP 0641785; JP 1993505096; US 5674886; WO 9305027

合成路线图解说明: The arylation of 1,2,4-triazol-4-amine (I) with 4-fluorobenzonitrile (II) by means of NaH in DMSO gives 4-(1,2,4-triazol-4-ylamino)benzonitrile (III), which is then condensed with 4-bromobenzyl bromide (III) by means of K2CO3 in acetonitrile.

参考文献No.	364439
标题:	YM-511
作者:	Mealy, N.; Casta馿r, J.
来源:	Drugs Fut 1996,21(7),716

合成路线图解说明: The arylation of 1,2,4-triazol-4-amine (I) with 4-fluorobenzonitrile (II) by means of NaH in DMSO gives 4-(1,2,4-triazol-4-ylamino)benzonitrile (III), which is then condensed with 4-bromobenzyl bromide (III) by means of K2CO3 in acetonitrile.