【药物名称】KF-19418
化学结构式(Chemical Structure):
参考文献No.19943
标题:Condensed naphthyridine derivs.
作者:Suzuki, F.; Kawakita, T.; Kuroda, T.; Ohmori, K.; Nakajima, H.; Kamiya, T.; Tamaoki, T. (Kyowa Hakko Kogyo Co., Ltd.)
来源:EP 0526840; JP 1993194515; US 5281610
合成路线图解说明:

Friedel-Crafts acylation of 4-hydroxy-1-phenyl[1,8]naphthyridin-2(1H)-one (I) with benzoyl chloride (II) using AlCl3 in hot nitrobenzene produced the 3-benzoyl naphthyridinone (III). This was cyclized to the title pyrazolonaphthyridinone by treatment with hydrazine in refluxing HOAc.

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